A polycistronic miRNA cluster miR-17-92 plays a role in the control of cell proliferation and angiogenesis. This cluster consists of seven miRNAs: miR-17-5p, miR-17-3p, miR-18a, miR-19a, miR-19b, miR-20a, and miR-92. Like E2F1 gene, the cluster is transcriptionally activated by the proto-oncogene c-Myc.

We dissected the role of individual miRNA components of the miR-17-92 cluster in thyroid differentiation, especially the impact on NIS levels, and observed that while some miRNAs such as miR-17-5p, miR-19a/b, and miR-92 may inhibit NIS expression, others such as miR-20a-5p do not modulate NIS levels.

The MicroRNA-17-92 cluster enhances axonal outgrowth in embryonic cortical The miR-17-92 cluster was among the first miRs that were linked to tumor angiogenesis. The miR-17-92 cluster is a typical example of a polycistronic miR cluster encoding the miRs miR-17, miR-18a, miR-19a/b, miR-20a, and miR-92a, which are highly expressed in several tumors. 16 Particularly, miR-17 and miR-20a were shown to control cellular proliferation and apoptosis by targeting the E2F As discussed, the mir-17-92 cluster has been proposed to have a functional relationship with Patched signalling. An abnormal functioning of which can induce the GNP tumours typical of Medullablastoma. This hypothesis was arrived at by taking miRNA expression profiles of GNP-like tumour cells from mouse mutants. Usually, miRNA clusters consist of two or three miRNAs, but larger clusters also exist, for example, the miR-17-92 cluster is found on human chromosome 13 and is composed of six miRNAs. miRNA clusters play important roles by controlling various cellular processes.

They found that overexpression of the entire cluster, the cluster without miR-92, but not when miR-19a and miR-19b were lost, enhanced oncogenesis. The miR-17-92 cluster is often amplified or overexpressed in human cancers and has recently emerged as the prototypical oncogenic polycistron miRNA. The functional analysis of miR-17-92 is intricate by the existence of two paralogues: miR-106a-363 and miR-106b-25. This miRNA dose-dependent target selection was also confirmed in other target genes, including CCND1, CDKN1 and E2F1. After overexpressing let-7a-7f or the miR-17-92 clusters at wide-ranging doses, the target genes displayed a nonlinear correlation to the transfected miRNA. Dysregulated miRNA expression is observed in PKD, but whether miRNAs are directly involved in kidney cyst formation and growth is not known.

Because of its strong oncogenic activity, the miR-17-92 cluster was also named as oncomiR-1. Thus, here we asked whether the placement of miRNAs in an miRNA cluster contributes to determining the miRNA expression patterns by investigating the relationship between expression and placement of miRNAs in the miR-17-92 cluster. Microarray profiling of cultured oligodendrocytes identified the miR-17-92 miRNA cluster as highly enriched in oligodendrocytes.

The miR-17-92 gene cluster, a polycistron encoding six microRNAs (miRNA), is frequ … In mammalian cells, activation of oncogenes usually triggers innate tumor-suppressing defense mechanisms, including apoptosis and senescence, which are compromised by additional mutations before cancers are developed.

In the present study, by specific ablation of this cluster in 2009-02-24 Microarray profiling of cultured oligodendrocytes identified the miR-17-92 miRNA cluster as highly enriched in oligodendrocytes. We specifically deleted the miR-17-92 cluster in oligodendrocytes using 2,3 -cyclic nucleotide 3 phosphodiesterase (Cnp)-Cre mice. Absence of miR-17-92 leads to a reduction in oligodendrocyte number in vivo and we Abstract: The human polycistronic miRNA cluster miR-17-92 is frequently overexpressed in hematopoietic malignancies and cancers.

Circulation 2011;123(12): (8) Mogilyansky E, Rigoutsos I. The mir-17/92 cluster: a comprehensive update on its genomics, genetics, functions and increasingly

An abnormal functioning of which can induce the GNP tumours typical of Medullablastoma.

mir-17–92 cluster is a miRNA polycistron located at chromosome 13q31, a genomic locus that is amplified in lung cancer and several kinds of lymphoma, including diffuse large B-cell lymphoma (Hayashita et al., 2005, He et al., 2005b). Usually, miRNA clusters consist of two or three miRNAs, but larger clusters also exist, for example, the miR-17-92 cluster is found on human chromosome 13 and is composed of six miRNAs. miRNA miR-17∼92 miRNA Cluster Is Up-Regulated in Mouse Models of PKD. To identify miRNAs that are differentially expressed between cystic kidneys and normal kidneys, we performed miRNA microarrays using RNA from kidneys of control and kidney-specific-cadherin (Ksp)/cre;Kif3a F/F (Kif3a-KO) mice, an animal model of PKD. The miR-17~92 cluster in cancer pathogenesis.
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Now more than 300 miRNA clusters are found in the human genome, including miR-183-96-182 cluster, miR-35-41 cluster, miR-17-92 cluster and so on. MiR-17-92 cluster is involved in the development of multiple organs in mammals and closely related to the development and occurrence of tumors, thus it receives widespread attention in the world [ 9 ]. The miR-17-92 cluster is often amplified or overexpressed in human cancers and has recently emerged as the prototypical oncogenic polycistron miRNA.

The miRNA expression profiles of THY1-enriched undifferentiated spermatogonia were characterized, and members of Mir-17-92 (Mirc1) and its paralog Mir-106b-25 (Mirc3) clusters are significantly downregulated during retinoic acid-induced spermatogonial differentiation, both in vitro and in vivo. Signosis has developed miR-17-92 cluster real-time PCR kit to detect the expression of miR-17-92 simultaneously in a high sensitive and discriminative manner.
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The miR-17-92 cluster was among the first miRs that were linked to tumor angiogenesis. The miR-17-92 cluster is a typical example of a polycistronic miR cluster encoding the miRs miR-17, miR-18a, miR-19a/b, miR-20a, and miR-92a, which are highly expressed in several tumors. 16 Particularly, miR-17 and miR-20a were shown to control cellular proliferation and apoptosis by targeting the E2F

3. Expression and regulation of the miRNA-17-92 cluster in tumor cells Expression and functions of miR-17/20a.

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The Oncogenic Relevance of miR-17-92 Cluster and Its Paralogous miR-106b- 25 and miR-106a-363 Clusters in Brain Tumors. by. Renata Gruszka. * and.

(A) Expression profiling of the miRNA cluster in 72 acute leukemic and normal samples as detected by the bead-based method. 2012-10-01 Increasing evidence indicates that microRNAs (miRNAs) may be critical players in spermatogenesis. The miRNA expression profiles of THY1-enriched undifferentiated spermatogonia were characterized, and members of Mir-17-92 (Mirc1) and its paralog Mir-106b-25 (Mirc3) clusters are significantly downregulated during retinoic acid-induced spermatogonial differentiation, both in vitro and in vivo. 2020-06-17 2018-04-18 The miR-17/92 cluster is also known as ‘oncomiR-1’. The miR-17/92 cluster is very often dysregylated in hematopoietic and solid cancers. Are there any protein-coding genes that are important forThe miR-17/92 cluster is often dysregylated in cardiovas-cular, immune and neurodegenerative diseases.